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BiologyCBSE Class 11 · Chapter 10

Cell Cycle and Cell Division Class 11 Biology: Interphase, Mitosis and Meiosis

Updated 15 October 2026 · Fact-checked

Cell Cycle and Cell Division is Chapter 10 of CBSE Class 11 Biology, in Unit III, Cell: Structure and Function. It covers the phases of the cell cycle (G1, S, G2, M and G0), the four stages of mitosis and cytokinesis, meiosis I with the five substages of prophase I, meiosis II, and why both divisions matter.

What Cell Cycle and Cell Division is about

Every organism, however big, starts as a single cell, the zygote. It grows by cell division, and new cells keep forming throughout life to replace worn-out ones. The sequence of events by which a cell duplicates its genome, makes other cell parts and finally divides into two is the cell cycle. Cell growth (a continuous process) and DNA synthesis (only in one stage) must be coordinated so that each daughter cell gets a complete genome.

Two kinds of division:

  • Mitosis (equational division): one diploid cell → two cells with the same chromosome number and identical genetic material. Used for growth, repair and replacement.
  • Meiosis (reduction division): one diploid cell → four haploid cells, each with half the chromosomes and new gene combinations. Used to make gametes.

Big picture flow chart:
G1 (growth) → S (DNA 2C → 4C) → G2 (proteins for division) → M phase (prophase → metaphase → anaphase → telophase → cytokinesis) → two daughter cells → G1 again, or exit to G0.

Two numbers to track: the chromosome number (counted by centromeres, written n or 2n) and the DNA content (written C). S phase doubles the DNA but not the chromosome number; anaphase separates chromatids; meiosis I halves the chromosome number.

This chapter is part of Unit III, which carries 15 of the 70 theory marks. Expect labelled diagrams of mitotic stages, the stages of prophase I, comparison of mitosis and meiosis, plant vs animal cytokinesis, and numericals on chromosome number and DNA content.

Weightage: This chapter is part of Unit III, Cell: Structure and Function, which carries 15 of the 70 theory marks in the school annual exam together with Cell: The Unit of Life and Biomolecules.Source: CBSE Biology (044) syllabus 2026-27, Class XI course structure, Unit III Cell: Structure and Function

Key concepts

The cell cycle: interphase and M phase
NCERT section 10.1 Cell Cycle (10.1.1 Phases of Cell Cycle)

Duration: human cells in culture divide roughly once every 24 hours; yeast completes a cycle in about 90 minutes. The length varies between organisms and between cell types.

Two basic phases:

  • Interphase: the period between two M phases. Though called the 'resting phase', the cell is busy growing and replicating DNA in an orderly way. It lasts more than 95% of the cycle.
  • M phase (mitosis phase): the actual division. In a 24-hour human cycle, division proper lasts only about an hour. It begins with karyokinesis (nuclear division, separating daughter chromosomes) and usually ends with cytokinesis (division of cytoplasm).

Three sub-phases of interphase:
1. G1 (Gap 1): between mitosis and the start of DNA replication. The cell is metabolically active and grows, but does not copy its DNA.
2. S (Synthesis): DNA replication. DNA per cell doubles from 2C to 4C, but the chromosome number stays the same (2n), because each chromosome now has two sister chromatids joined at one centromere. In animal cells, the centriole duplicates in the cytoplasm during S phase while DNA replicates in the nucleus.
3. G2 (Gap 2): proteins are made in preparation for mitosis and growth continues.

G0 (quiescent stage): cells that stop dividing exit G1 into G0. They stay metabolically active but do not multiply unless the body needs them to. Example: heart cells in adults do not seem to divide; many other cells divide only occasionally to replace cells lost by injury or death.

Who divides by mitosis? In animals, mitosis is seen only in diploid somatic cells, with a few exceptions such as male honey bees (haploid cells divide by mitosis). Plants show mitosis in both haploid and diploid cells (e.g. the haploid gametophyte of mosses and ferns).

Worked example

A diploid cell in G1 has 2C DNA and 16 chromosomes. State its DNA content and chromosome number in G2, and explain why only one of the two values changes. (3 marks)

Try it first, then show the solutionSolution
  1. G2: DNA = 4C; chromosomes = 16. (1)
  2. During S phase each DNA molecule is copied, so DNA doubles. (1)
  3. The two copies stay as sister chromatids attached at one centromere; chromosomes are counted by centromeres, so the number does not change. (1)

Answer: 4C and 16 chromosomes; DNA doubles but chromatids share a centromere.

Mitosis: prophase and metaphase
NCERT section 10.2 M Phase (10.2.1 Prophase; 10.2.2 Metaphase)

Mitosis is called equational division because the parent and daughter cells have the same number of chromosomes. It is divided into four stages for convenience, but it is a continuous process with no sharp boundaries.

Prophase (follows S and G2, whose new DNA molecules are intertwined):

  • Chromosomal material condenses into compact mitotic chromosomes; each chromosome is seen to have two chromatids attached at the centromere.
  • The centrosome, which duplicated during interphase, begins to move towards opposite poles. Each centrosome radiates microtubules called asters; the two asters with spindle fibres form the mitotic apparatus.
  • At the end of prophase, the Golgi complex, ER, nucleolus and nuclear envelope are no longer seen under the microscope.

Metaphase:

  • Begins with the complete disintegration of the nuclear envelope, so chromosomes spread through the cytoplasm.
  • Chromosome condensation is complete; this is the best stage to study chromosome morphology. Each chromosome shows two sister chromatids held by the centromere.
  • Small disc-shaped kinetochores on the surface of the centromere are the sites where spindle fibres attach.
  • Chromosomes move to the spindle equator; one chromatid of each is attached by its kinetochore to fibres from one pole and its sister to fibres from the opposite pole.
  • The plane where chromosomes line up is the metaphase plate.

Key features: spindle fibres attach to kinetochores; chromosomes align at the equator.

Worked example

Why is metaphase the best stage to count and study chromosomes? Name the structure through which spindle fibres attach to a chromosome. (2 marks)

Try it first, then show the solutionSolution
  1. Chromosomes are fully condensed and lie spread in one plane (metaphase plate), so their shape and number are clearest. (1)
  2. Kinetochores, disc-shaped structures on the centromere. (1)

Answer: Maximum condensation and alignment; kinetochores.

Mitosis: anaphase, telophase and cytokinesis
NCERT section 10.2.3 Anaphase; 10.2.4 Telophase; 10.2.5 Cytokinesis; 10.3 Significance of Mitosis

Anaphase:

  • Each chromosome at the metaphase plate splits at the centromere; the two sister chromatids, now daughter chromosomes, begin moving to opposite poles.
  • As they move, the centromere leads and the arms trail behind.

Telophase (final stage of karyokinesis):

  • Chromosomes reach the poles and decondense, losing their individuality; chromatin collects at each pole.
  • The nuclear envelope reassembles around each cluster, forming two daughter nuclei.
  • Nucleolus, Golgi complex and ER reform.

Cytokinesis (division of the cytoplasm), completing cell division:

  • Animal cells: a furrow appears in the plasma membrane and deepens until it meets in the centre, splitting the cytoplasm in two (outside → inside).
  • Plant cells: the wall is relatively inextensible, so a furrow cannot form. Wall formation starts in the centre and grows outward to meet the side walls (inside → outside). It begins with a simple precursor, the cell plate, which becomes the middle lamella between the two new cells.
  • Organelles such as mitochondria and plastids are shared between the daughter cells.
  • Syncytium: in some organisms karyokinesis is not followed by cytokinesis, producing a multinucleate cell, e.g. the liquid endosperm of coconut.

Significance of mitosis:
1. Produces diploid daughter cells with identical genetic material (usually restricted to diploid cells; haploid cells in some lower plants and social insects also divide by mitosis).
2. Growth of multicellular organisms.
3. Restores the nucleo-cytoplasmic ratio, which is disturbed as a cell grows.
4. Cell repair and replacement: upper epidermis, gut lining and blood cells are constantly replaced.
5. Mitosis in meristems (apical meristem and lateral cambium) lets plants grow throughout life.

Worked example

(a) A nucleus goes through three successive rounds of karyokinesis, but no cytokinesis follows any of them. How many nuclei does the cell now hold, what is such a cell called, and where is one found naturally? (b) Why must a dividing plant cell build a cell plate instead of forming a furrow? (3 marks)

Try it first, then show the solutionSolution
  1. (a) Each karyokinesis doubles the number of nuclei: 1 → 2 → 4 → 8 nuclei (2³ = 8). (1)
  2. A multinucleate cell formed this way is a syncytium; the liquid endosperm of coconut is an example. (1)
  3. (b) The plant cell wall is relatively inextensible and cannot be pinched in, so a new wall is laid down from the centre outwards, starting as the cell plate that becomes the middle lamella. (1)

Answer: 8 nuclei, a syncytium (liquid endosperm of coconut); the rigid wall rules out a furrow, so a cell plate grows outwards from the centre.

Meiosis: key features and prophase I
NCERT section 10.4 Meiosis (10.4.1 Meiosis I, prophase I)

Meiosis is the special division that halves the chromosome number, producing haploid cells. It occurs during gametogenesis in plants and animals. Meiosis creates the haploid phase of the life cycle; fertilisation restores the diploid phase.

Key features:

  • Two sequential divisions (meiosis I and meiosis II) but only one round of DNA replication.
  • Meiosis I starts after the chromosomes have replicated in S phase to form identical sister chromatids.
  • Pairing of homologous chromosomes and recombination between non-sister chromatids of homologues.
  • Four haploid cells form at the end of meiosis II.

Prophase I is longer and more complex than mitotic prophase, with five substages:
1. Leptotene: chromosomes gradually become visible under the light microscope; compaction continues.
2. Zygotene: homologous chromosomes start pairing: synapsis. A complex structure, the synaptonemal complex, forms between them. A synapsed pair of homologues is a bivalent or tetrad (four chromatids).
3. Pachytene: the four chromatids of each bivalent become distinct and clear. Recombination nodules appear: sites of crossing over between non-sister chromatids. Crossing over is the exchange of genetic material between two homologues, catalysed by the enzyme recombinase. It leads to recombination of genetic material. Crossing over is completed by the end of pachytene, leaving homologues linked at the crossing-over sites.
4. Diplotene: the synaptonemal complex dissolves and the recombined homologues tend to separate, except at the sites of crossover. These X-shaped points are chiasmata. In the oocytes of some vertebrates, diplotene can last for months or years.
5. Diakinesis: terminalisation of chiasmata (they move towards the chromosome ends). Chromosomes are fully condensed and the meiotic spindle assembles. By the end, the nucleolus disappears and the nuclear envelope breaks down. Diakinesis is the transition to metaphase I.

Memory flow: Leptotene (threads appear) → Zygotene (pairing) → Pachytene (crossing over) → Diplotene (chiasmata seen) → Diakinesis (chiasmata slide to ends).

Worked example

Name the substage of prophase I in which (a) the synaptonemal complex forms, (b) crossing over occurs, (c) chiasmata first become visible, (d) chiasmata terminalise. Name the enzyme involved in crossing over. (3 marks)

Try it first, then show the solutionSolution
  1. (a) Zygotene (½) (b) pachytene (½)
  2. (c) Diplotene (½) (d) diakinesis (½)
  3. Recombinase. (1)

Answer: Zygotene, pachytene, diplotene, diakinesis; recombinase.

Meiosis I (metaphase I to telophase I), interkinesis and meiosis II
NCERT section 10.4.1 Meiosis I; 10.4.2 Meiosis II; 10.5 Significance of Meiosis

Metaphase I: the bivalents line up on the equatorial plate. Microtubules from opposite poles attach to the kinetochores of the two homologous chromosomes (not of sister chromatids).

Anaphase I: homologous chromosomes separate and move to opposite poles, but sister chromatids stay together at their centromeres. Each pole therefore receives half the chromosome number. *This is the reduction step.*

Telophase I: nuclear membrane and nucleolus reappear; cytokinesis follows. The two cells formed are a dyad of cells. Chromosomes may not decondense fully.

Interkinesis: the stage between the two divisions; usually short-lived, with no DNA replication.

Meiosis II (resembles a normal mitosis):

  • Prophase II: begins immediately after cytokinesis, usually before chromosomes have fully elongated; simpler than prophase I. Nuclear membrane disappears and chromosomes become compact again.
  • Metaphase II: chromosomes align at the equator; microtubules from opposite poles attach to the kinetochores of sister chromatids.
  • Anaphase II: the centromere of each chromosome splits (it had held sister chromatids together), and chromatids move to opposite poles as microtubules attached to kinetochores shorten.
  • Telophase II: two groups of chromosomes get enclosed by a nuclear envelope; cytokinesis follows, forming a tetrad of cells: four haploid daughter cells.

Significance of meiosis:
1. Conserves the species' chromosome number across generations in sexually reproducing organisms, even though the division itself halves the number (fertilisation restores it).
2. Increases genetic variability in the population from one generation to the next, through crossing over and the random separation of homologues. Variations are important for evolution.

Worked example

In anaphase I, what separates, and in anaphase II, what separates? Why is meiosis II described as similar to mitosis? (3 marks)

Try it first, then show the solutionSolution
  1. Anaphase I: homologous chromosomes separate; sister chromatids remain joined at the centromere. (1)
  2. Anaphase II: centromeres split and sister chromatids separate. (1)
  3. Meiosis II does not change the chromosome number (n → n) and separates sister chromatids, just as mitosis does. (1)

Answer: Homologues in anaphase I; sister chromatids in anaphase II; meiosis II is equational like mitosis.

Tracking chromosome number and DNA content (numericals)
NCERT section 10.1.1 Phases of Cell Cycle; 10.2 M Phase; 10.4 Meiosis

Two quantities change differently through division. Learn to tabulate them.

Rules:

  • Chromosome number = number of centromeres. It changes only when centromeres split (anaphase of mitosis or anaphase II) or when homologues go to different cells (meiosis I).
  • DNA content (C): a haploid set of unreplicated chromosomes = 1C. Doubles in S phase, halves whenever a cell divides.

Mitosis of a diploid cell (2n):

  • G1: 2n, 2C
  • S → G2: 2n, 4C
  • Prophase and metaphase: 2n, 4C (each chromosome has two chromatids)
  • Anaphase (one cell, both sets of daughter chromosomes): 4n, 4C
  • After cytokinesis, each daughter cell: 2n, 2C

Meiosis of a diploid cell (2n):

  • After S: 2n, 4C
  • After meiosis I (each cell): n, 2C (each chromosome still has two chromatids)
  • After meiosis II (each cell): n, 1C

Counting cells:

  • After *k* rounds of mitosis from one cell: 2^k cells.
  • One meiosis: 4 haploid cells from one meiocyte; so *N* gametes need N ÷ 4 meiotic divisions (in males, where all four products are functional).

Tip: always write the starting values (n and C) given in the question before working, and say whether you are counting per cell or per nucleus at that stage.

Worked example

An onion root-tip cell has 16 chromosomes in G1. How many chromatids are present at metaphase, and how many chromosomes are present in the cell at anaphase? (2 marks)

Try it first, then show the solutionSolution
  1. Metaphase: 16 chromosomes, each with 2 chromatids = 32 chromatids. (1)
  2. Anaphase: centromeres split, so each chromatid becomes a chromosome: 32 chromosomes in the cell (16 moving to each pole). (1)

Answer: 32 chromatids at metaphase; 32 chromosomes at anaphase.

Cell Cycle and Cell Division in real life

Each concept, met in an everyday situation. Read the situation, answer the question in your own words, then compare with the model answer. The one-line hook is what to remember.

Mitosis: anaphase, telophase and cytokinesis

Suppose you scrape your knee playing football and, about two weeks later, the wound has closed with new skin that matches the old skin exactly.

Which type of division repaired the skin, and why is the new skin genetically identical to the old?

Try it first, then show the solutionSolution
  1. Skin cells around the wound divide by mitosis to replace lost cells.
  2. In mitosis, the DNA is copied once and the sister chromatids are shared equally between two daughter cells.
  3. So each new cell has the same chromosome number and genes as the parent cell.

Answer: Mitosis; equational division gives identical daughter cells.

Memory hook: Mitosis mends; meiosis mixes.

Meiosis I (metaphase I to telophase I), interkinesis and meiosis II

Imagine two brothers born to the same parents who look quite different from each other, even though each got half his chromosomes from each parent.

Explain how meiosis makes brothers (who are not identical twins) genetically different.

Try it first, then show the solutionSolution
  1. During pachytene, non-sister chromatids of homologous chromosomes exchange segments by crossing over, forming new gene combinations.
  2. During anaphase I, each pair of homologues separates independently, so each gamete gets a different mix of maternal and paternal chromosomes.
  3. Different sperm and eggs therefore carry different combinations, and so do the zygotes formed from them.

Answer: Crossing over and random separation of homologues in meiosis create variation.

Memory hook: Shuffle in pachytene, deal in anaphase I.

The cell cycle: interphase and M phase

Suppose a doctor explains that some cancer drugs damage rapidly dividing cells, which is why patients may lose hair and have stomach upsets, while heart muscle is barely affected.

Use the cell cycle to explain why heart cells are spared.

Try it first, then show the solutionSolution
  1. Hair follicle cells and gut lining cells divide often to replace lost cells, so they are frequently in S and M phases.
  2. Adult heart cells have left the cycle and stay in G0, the quiescent stage; they are metabolically active but do not divide.
  3. Drugs that target dividing cells therefore hit hair and gut cells but largely spare heart cells.

Answer: Heart cells are in G0 and do not divide.

Memory hook: G0 = 'gone off' the cycle.

Topics in this chapter

Cell Cycle and Cell Division: key facts

Cell cycle
Interphase = G1 + S + G2 (more than 95% of the cycle).
DNA change in S phase
DNA doubles; chromosome number unchanged.
Mitosis stages
2n parent → two 2n daughters (equational).
Prophase I substages
Synapsis in zygotene; crossing over in pachytene; chiasmata in diplotene.
Meiosis counts
One meiocyte gives four haploid cells.
Cells after repeated mitosis
k = number of successive mitotic divisions starting from one cell.

Cell Cycle and Cell Division: diagrams to practise

Practise each one on paper: draw it from the checklist, then tick off every label.

Stages of mitosis in an animal cell (2n = 4)

Draw labelled diagrams of the stages of mitosis.

Draw

  1. Interphase/early prophase: round nucleus with nucleolus and thread-like chromatin; two centriole pairs beside it.
  2. Late prophase: condensed chromosomes, each with two chromatids; asters at opposite poles; nuclear envelope fading.
  3. Metaphase: four chromosomes on the equator; spindle fibres from both poles to the kinetochores.
  4. Anaphase: V-shaped daughter chromosomes moving to poles, centromere first.
  5. Telophase: chromosome groups at poles with new nuclear envelopes; furrow starting.

Label

  • Centriole
  • Aster
  • Spindle fibre
  • Chromatid
  • Centromere / kinetochore
  • Metaphase plate
  • Daughter chromosome
  • Nuclear envelope
  • Cleavage furrow

Watch out: Use the same 2n = 4 throughout (two long, two short) so the examiner can follow the chromosomes.

Bivalent with chiasmata (diplotene)

Draw a bivalent showing chiasmata, or illustrate synapsis, bivalent and chiasmata.

Draw

  1. Two homologous chromosomes side by side, each with two chromatids (four strands in all).
  2. Two places where a chromatid of one homologue crosses a chromatid of the other (X shapes).
  3. Mark centromeres as small circles on each homologue.

Label

  • Homologous chromosome
  • Sister chromatids
  • Non-sister chromatids
  • Chiasma
  • Centromere
  • Bivalent (tetrad)

Watch out: Crossing over is always between non-sister chromatids; show the swapped colour or shading beyond the chiasma.

Cell cycle wheel

Draw a diagram of the cell cycle showing its phases.

Draw

  1. A circle divided into sectors: a large G1, an S, a G2 and a small M sector.
  2. An arrow out of G1 to a small circle labelled G0.
  3. Mark 'Interphase' over G1 + S + G2.

Label

  • G1 phase
  • S phase
  • G2 phase
  • M phase
  • Interphase
  • G0 (quiescent)

Watch out: Keep M about 1/24 of the circle to show it is short.

How the school exam asks Cell Cycle and Cell Division

The question patterns to expect, and the method that works for each.

Question typeHow it is askedMethod
Identify the stage (1 mark)Stage at which the nuclear envelope disappears, chromosomes align, centromeres split, synapsis or crossing over happens, chiasmata terminalise.Name the exact stage (and substage for prophase I).
Describe a phase (3 marks)Events of interphase, prophase, metaphase, anaphase, telophase, prophase I substages.Three or four key events in order, using exact terms (kinetochore, metaphase plate, synaptonemal complex).
Comparisons (2-5 marks)Plant vs animal cytokinesis; anaphase vs anaphase I; mitosis vs meiosis; karyokinesis vs cytokinesis.Matched points in a table; always include chromosome number and what separates.
Diagrams (3-5 marks)Stages of mitosis in an animal cell; bivalent with chiasmata; metaphase I vs metaphase II.Use a small number of chromosomes (2n = 4) so the drawing is clear; label poles, spindle, kinetochores.
Numericals (2-3 marks)Chromosome number and DNA content at given stages; number of cells after k mitoses; number of meioses for N gametes.Tabulate n and C stage by stage; count chromosomes by centromeres.

Tricks to remember Cell Cycle and Cell Division

Short memory aids. Say each one aloud once, then use it on a question the same day.

  • PMAT

    Prophase, Metaphase, Anaphase, Telophase: 'Please Make A Tea'.

    Use it when: Order of mitotic stages.

  • Lazy Zebras Prefer Dry Dates

    Leptotene, Zygotene, Pachytene, Diplotene, Diakinesis.

    Use it when: Order of prophase I substages.

  • Z for Zip, P for Pass

    Zygotene zips homologues together (synapsis); Pachytene passes genes across (crossing over).

    Use it when: Linking substages to events.

  • A-I splits pairs, A-II splits twins

    Anaphase I separates homologous pairs; anaphase II (and mitotic anaphase) separates sister chromatids (twins).

    Use it when: What separates in each anaphase.

  • Animals pinch in, plants build out

    Animal cytokinesis: furrow from outside inwards. Plant cytokinesis: cell plate from centre outwards.

    Use it when: Comparing cytokinesis.

Cell Cycle and Cell Division: exam-level solved questions

Ordered from exam level to HOTS. Cover the solution, write your own, then compare step by step.

Example 1: Longest phase · 1 mark · MCQExam level

Which phase occupies more than 95% of the cell cycle?
(a) Prophase (b) M phase (c) Interphase (d) Telophase

Try it first, then show the solutionSolution
  1. In a 24-hour human cycle, M phase lasts about one hour; the rest is interphase.

Answer: (c) Interphase

Example 2: Cytokinesis in coconut · 1 mark · Assertion-reasonExam level

Assertion (A): The liquid endosperm of coconut is multinucleate.
Reason (R): In it, karyokinesis is not followed by cytokinesis.
(a) Both A and R are true and R is the correct explanation of A.
(b) Both A and R are true but R is not the correct explanation of A.
(c) A is true but R is false.
(d) A is false but R is true.

Try it first, then show the solutionSolution
  1. Nuclei divide without cytoplasm dividing, forming a syncytium; R explains A.

Answer: (a)

Example 3: Kinetochores · 2 marks · Very short answerExam level

What are kinetochores, and what is their role at metaphase of mitosis? (2 marks)

Try it first, then show the solutionSolution
  1. Small disc-shaped structures on the surface of the centromere. (1)
  2. Spindle fibres attach to them; each sister chromatid's kinetochore connects to fibres from opposite poles, aligning chromosomes at the equator. (1)

Answer: Disc-shaped centromere structures where spindle fibres attach.

Example 4: Counting cells after mitosis (solved two ways) · 2 marks · Very short answerHarder exam level

A single cell divides by mitosis repeatedly, every daughter dividing each time. How many rounds of division are needed to produce 128 cells? (2 marks)

Try it first, then show the solutionSolution
  1. Method 1 (doubling list): 1 → 2 → 4 → 8 → 16 → 32 → 64 → 128: that is 7 rounds. (1)
  2. Method 2 (powers of 2): 2^k = 128 = 2^7, so k = 7. (1)

Answer: 7 rounds of mitosis.

Example 5: DNA content through meiosis (solved two ways) · 3 marks · Short answerHarder exam level

A meiocyte of a plant (2n = 24) has 6 pg of DNA in G1. Find the chromosome number and DNA content per cell (a) at G2, (b) after telophase I, (c) after telophase II. (3 marks)

Try it first, then show the solutionSolution
  1. Method 1 (stage by stage): G1 24 chromosomes, 6 pg. S doubles DNA: G2 24 chromosomes, 12 pg. Meiosis I halves both chromosomes and DNA per cell: 12 chromosomes, 6 pg. Meiosis II separates chromatids: 12 chromosomes, 3 pg. (2)
  2. Method 2 (C notation): 6 pg in G1 = 2C, so 1C = 3 pg. G2 = 4C = 12 pg; after meiosis I = 2C = 6 pg; after meiosis II = 1C = 3 pg. Chromosomes: 2n = 24, then n = 12, n = 12. (1)
  3. Both methods agree.

Answer: (a) 24, 12 pg (b) 12, 6 pg (c) 12, 3 pg.

Example 6: Metaphase I vs metaphase II · 2 marks · Very short answerHarder exam level

Give two differences between metaphase I and metaphase II of meiosis. (2 marks)

Try it first, then show the solutionSolution
  1. Metaphase I: bivalents (homologous pairs) line up; metaphase II: single chromosomes (each with two chromatids) line up. (1)
  2. Metaphase I: fibres from opposite poles attach to the kinetochores of the two homologues; metaphase II: to the kinetochores of the two sister chromatids. (1)

Answer: Bivalents vs single chromosomes; fibres to homologues vs to sister chromatids.

Example 7: Centromeres that cannot split · 3 marks · Short answerHOTS / competency

A chemical stops centromeres from splitting but leaves the spindle working normally. Predict what you would see (a) in a root-tip cell at mitotic anaphase, and (b) in a meiocyte at anaphase I. Explain each. (3 marks)

Try it first, then show the solutionSolution
  1. (a) In mitotic anaphase the centromere of each chromosome must split so that sister chromatids can move to opposite poles; with the centromeres held, chromatids cannot separate and division stalls after metaphase. (1)
  2. So the root-tip cell would not complete karyokinesis and would not form two daughter nuclei. (1)
  3. (b) Anaphase I would look normal: homologous chromosomes separate while sister chromatids stay joined at their centromeres anyway. The block would show up only at anaphase II, when centromeres normally split. (1)

Answer: Mitosis stalls after metaphase (chromatids cannot part); anaphase I proceeds normally, and meiosis is blocked only at anaphase II.

Example 8: Why meiosis keeps chromosome number constant · 3 marks · Short answerHOTS / competency

A student argues: 'Meiosis halves the chromosome number, so it must reduce the chromosome number of a species over generations.' Explain why this is wrong and what meiosis actually achieves. (3 marks)

Try it first, then show the solutionSolution
  1. Meiosis halves the number only in gametes (2n → n). (1)
  2. At fertilisation, two haploid gametes fuse and restore 2n in the zygote, so the species number stays constant generation after generation. (1)
  3. Without meiosis, each fertilisation would double the number; in addition, meiosis increases genetic variation through crossing over and independent separation of homologues. (1)

Answer: Halving in gametes is undone by fertilisation; meiosis conserves the number and adds variation.

Case-study practice (Section E style)

Read the situation, then answer every part. In a school exam set on the board pattern this is a 4-mark question split into 1 + 1 + 2 marks.

Onion root tip slide

Suppose a student examines a stained onion root tip slide (2n = 16) and counts 200 cells: 180 show an intact nucleus with no visible chromosomes, 10 show condensed chromosomes with no nuclear envelope lined up at the centre, 6 show two groups of chromosomes moving apart, and 4 show two nuclei with a new wall forming in the middle.

  1. (i) · 1 mark

    Which stage do most cells show, and what does this tell you?

    Answer

    Answer: Interphase; it is the longest part of the cell cycle.

    180 of 200 cells (90%) are in interphase.

  2. (ii) · 1 mark

    Identify the stage of the 6 cells and the 4 cells.

    Answer

    Answer: Anaphase; telophase with cytokinesis (cell plate).

    Chromosome groups moving apart = anaphase; two nuclei with a central wall = telophase/cytokinesis in a plant cell.

  3. (iii) · 2 marks

    How many chromosomes and chromatids does each of the 10 cells contain? Explain.

    Answer

    Answer: 16 chromosomes, 32 chromatids.

    These are metaphase cells (1); DNA has replicated so each of the 16 chromosomes has two sister chromatids, 16 × 2 = 32 (1).

Variation from one family

Imagine a pea plant (2n = 14) forms pollen grains by meiosis in its anthers. A biologist observes that in one meiocyte, a long chromosome pair shows two chiasmata and a short pair shows one.

  1. (i) · 1 mark

    How many bivalents form in each meiocyte?

    Answer

    Answer: 7.

    14 ÷ 2 = 7 homologous pairs.

  2. (ii) · 1 mark

    In which substage did the chromatid exchange occur, and where are chiasmata first seen?

    Answer

    Answer: Pachytene; diplotene.

    Crossing over occurs in pachytene; chiasmata become visible when the synaptonemal complex dissolves in diplotene.

  3. (iii) · 2 marks

    Why might a longer chromosome pair show more chiasmata, and what is the effect on the pollen?

    Answer

    Answer: More length allows more crossover sites; more recombination and more varied pollen.

    A longer pair offers more points for crossing over between non-sister chromatids (1), so more segments are exchanged and the pollen grains carry more new gene combinations (1).

Where the marks are

How a typical answer is split into step marks. Show every step: a right final answer alone rarely earns full marks.

What is the quiescent stage (G0)? Give an example of cells found in it. (2 marks) (2 marks)

StepMarks
Cells that stop dividing exit G1 and enter G0; they remain metabolically active but do not proliferate unless required.1
Example: adult heart cells.1

Describe the events of anaphase and telophase of mitosis. (3 marks) (3 marks)

StepMarks
Anaphase: centromeres split and sister chromatids (now daughter chromosomes) move to opposite poles, centromere leading and arms trailing.1
Telophase: chromosomes reach the poles and decondense, losing their individuality.1
Nuclear envelope reassembles around each group; nucleolus, Golgi complex and ER reform.1

Describe prophase I of meiosis with its five substages. (5 marks) (5 marks)

StepMarks
Leptotene: chromosomes become visible and continue compacting.1
Zygotene: homologues pair (synapsis) with a synaptonemal complex; pairs are bivalents/tetrads.1
Pachytene: recombination nodules appear; crossing over between non-sister chromatids, catalysed by recombinase.1
Diplotene: synaptonemal complex dissolves; homologues separate except at chiasmata.1
Diakinesis: chiasmata terminalise; chromosomes fully condensed; spindle forms; nucleolus and nuclear envelope disappear.1

Where students lose marks in Cell Cycle and Cell Division

The slips examiners see most often, and what to write instead.

  • Mistake: Saying chromosome number doubles in S phase

    DNA doubling is confused with chromosome doubling.

    Do this: S phase: DNA 2C → 4C; chromosome number remains 2n (chromatids share one centromere).

    Usually costs: 1 mark.

  • Mistake: Writing that crossing over happens in zygotene or diplotene

    Synapsis and chiasmata are mixed up with crossing over.

    Do this: Synapsis: zygotene. Crossing over: pachytene. Chiasmata visible: diplotene. Terminalisation: diakinesis.

    Usually costs: 1 mark.

  • Mistake: Saying centromeres split in anaphase I

    Anaphase I is treated like mitotic anaphase.

    Do this: In anaphase I, homologues separate and sister chromatids stay together; centromeres split in anaphase II.

    Usually costs: 1-2 marks.

  • Mistake: Calling interphase a resting phase where nothing happens

    The old name is taken literally.

    Do this: Interphase is the busiest time: growth (G1, G2) and DNA replication (S).

    Usually costs: ½-1 mark.

  • Mistake: Claiming DNA is replicated during interkinesis

    Assuming every division needs a fresh S phase.

    Do this: There is no DNA replication in interkinesis; meiosis has only one S phase.

    Usually costs: 1 mark.

NCERT exercise guide: Cell Cycle and Cell Division

What each exercise in the NCERT chapter tests, how to approach it, and a question of the same kind solved step by step. Questions here are written in our own words.

Exercises on the cell cycle and mitosis

What it tests: Cycle duration, interphase events, G0, equational division, stage identification, plant and animal cytokinesis.

How to approach it: Name the exact phase; give two or three events per phase; contrast mechanisms point by point.

Mitosis (own question)

A drug prevents the nuclear envelope from breaking down. At which stage would mitosis stop, and why?

Show the solutionSolution
  1. Complete disintegration of the nuclear envelope marks the start of metaphase.
  2. Without it, spindle fibres cannot reach the kinetochores and chromosomes cannot align, so division stalls in late prophase.

Answer: Late prophase; chromosomes cannot reach the spindle.

Exercises on meiosis and its significance

What it tests: Synapsis, bivalent, chiasmata, stage identification, mitosis vs meiosis, chromosome and DNA changes, significance.

How to approach it: Use the prophase I sequence; tabulate n and C for each stage; link meiosis to variation and constant chromosome number.

Meiosis (own question)

A plant has 2n = 20. How many bivalents form in prophase I, and how many chromosomes does each microspore receive?

Show the solutionSolution
  1. Each bivalent is one pair of homologues: 20 ÷ 2 = 10 bivalents.
  2. Microspores are haploid: n = 10 chromosomes.

Answer: 10 bivalents; 10 chromosomes.

Practice questions on Cell Cycle and Cell Division

Write each answer on paper first. Open the hint only if you are stuck, and the answer only when you have finished.

  1. Q1 · 1 mark · MCQExam level

    Crossing over takes place between:
    (a) sister chromatids of a chromosome (b) non-sister chromatids of homologous chromosomes (c) non-homologous chromosomes (d) two daughter cells

    Hint

    Pachytene.

    Answer

    (b) non-sister chromatids of homologous chromosomes

  2. Q2 · 1 mark · MCQExam level

    Terminalisation of chiasmata occurs in:
    (a) zygotene (b) pachytene (c) diplotene (d) diakinesis

    Hint

    Last substage.

    Answer

    (d) diakinesis

  3. Q3 · 2 marks · Very short answerExam level

    State what happens to the Golgi complex, ER, nucleolus and nuclear envelope by the end of prophase, and when they reappear. (2 marks)

    Hint

    Telophase rebuilds.

    Answer

    They are no longer seen at the end of prophase (1); they reform in telophase (1).

  4. Q4 · 2 marks · Very short answerHarder exam level

    Why is the restoration of the nucleo-cytoplasmic ratio a reason for cells to divide? (2 marks)

    Hint

    Growth disturbs balance.

    Answer

    As a cell grows, its cytoplasm increases while the nucleus does not, so one nucleus must control a larger volume (1). Division into two smaller cells restores a balanced nucleus-to-cytoplasm ratio (1).

  5. Q5 · 2 marks · Very short answerHarder exam level

    Explain what is meant by synapsis and the synaptonemal complex. (2 marks)

    Hint

    Zygotene.

    Answer

    Synapsis is the pairing of homologous chromosomes during zygotene (1); the synaptonemal complex is the structure formed between the paired homologues that holds them together (1).

  6. Q6 · 2 marks · Very short answerHarder exam level

    A plant cell has 2n = 18. Give the chromosome number in (a) a leaf cell, (b) the egg cell, (c) each cell after telophase I, (d) the cell at mitotic anaphase. (2 marks)

    Hint

    Count centromeres.

    Answer

    (a) 18 (b) 9 (c) 9 (d) 36 in the cell (18 moving to each pole) (½ each).

  7. Q7 · 3 marks · Short answerHarder exam level

    Explain how mitosis allows plants to grow throughout their lives, and name two kinds of animal cells continuously replaced by mitosis. (3 marks)

    Hint

    Meristems; skin, gut, blood.

    Answer

    Meristematic tissues (apical meristem and lateral cambium) keep dividing by mitosis, adding cells for growth in length and girth (2). In animals, cells of the upper epidermis, gut lining or blood cells are constantly replaced (any two) (1).

  8. Q8 · 3 marks · Short answerHarder exam level

    A cell completes one cycle in 20 hours, and M phase takes 4% of this time. G1 lasts 9 hours and S phase 6 hours. (a) Find the duration of M phase and of interphase. (b) How long is G2? (c) State the main event in each of G1, S and G2. (3 marks)

    Hint

    Interphase = G1 + S + G2 = whole cycle minus M.

    Answer

    (a) M phase = 4% of 20 h = 0.8 h (48 minutes); interphase = 20 − 0.8 = 19.2 h (1). (b) G2 = 19.2 − 9 − 6 = 4.2 h (1). (c) G1: cell grows and is metabolically active without copying DNA; S: DNA replicates (2C → 4C) with chromosome number unchanged; G2: proteins for mitosis are made while growth continues (1).

  9. Q9 · 5 marks · Long answerHarder exam level

    (a) Describe the events of meiosis II. (b) State two ways in which meiosis contributes to variation. (c) Why is there no S phase before meiosis II? (5 marks)

    Hint

    Like mitosis; crossing over.

    Answer

    (a) Prophase II: nuclear membrane disappears, chromosomes compact; metaphase II: chromosomes at equator, fibres attach to kinetochores of sister chromatids; anaphase II: centromeres split, chromatids move to poles; telophase II: nuclear envelopes form, cytokinesis gives four haploid cells (2½). (b) Crossing over in pachytene creates new combinations; random separation of homologues at anaphase I gives different maternal-paternal mixes (1½). (c) Each chromosome already has two chromatids after meiosis I, so another replication is not needed; meiosis II only separates them (1).

  10. Q10 · 3 marks · Short answerHOTS / competency

    Suppose spindle fibres fail to form in a dividing plant cell after its chromosomes have replicated. Predict the chromosome number of the resulting cell and explain how such failure might be useful to plant breeders. (3 marks)

    Hint

    Chromatids separate but cannot move.

    Answer

    Without a spindle, chromatids cannot be pulled to two poles, and no division follows, so the nucleus ends up with doubled chromosomes: 2n becomes 4n (1½). Such cells give polyploid plants, which are often larger, with bigger fruits or flowers, useful to breeders (1½).

  11. Q11 · 3 marks · Short answerHOTS / competency

    Two cells from the same animal are observed: cell X has 23 chromosomes, each made of two chromatids; cell Y has 46 chromosomes, each made of one chromatid, arranged in two groups at opposite ends. Identify the likely stage of each and give reasons. (3 marks)

    Hint

    Human 2n = 46.

    Answer

    X: after meiosis I (telophase I or prophase II/metaphase II), since the cell is haploid (n = 23) but chromatids are still joined (1½). Y: anaphase II of meiosis, since the centromeres have split and 23 single-chromatid chromosomes are moving to each pole; a human cell at mitotic anaphase would instead show 92 chromosomes, 46 at each pole (1½).

  12. Q12 · 1 mark · Assertion-reasonHOTS / competency

    Assertion (A): Meiosis II is called an equational division.
    Reason (R): In meiosis II, sister chromatids separate and the chromosome number of the cells does not change.
    (a) Both A and R are true and R is the correct explanation of A.
    (b) Both A and R are true but R is not the correct explanation of A.
    (c) A is true but R is false.
    (d) A is false but R is true.

    Hint

    n stays n.

    Answer

    (a)

Test your recall

Answer in your head or on paper first, then open the card. Pulling an answer out of memory makes it stick far better than re-reading.

  1. 1.How long is the cell cycle of human cells in culture?Show answer

    About 24 hours.

  2. 2.How long does yeast take to complete a cell cycle?Show answer

    About 90 minutes.

  3. 3.In which phase does the centriole duplicate in animal cells?Show answer

    S phase.

  4. 4.Give an example of cells in G0.Show answer

    Adult heart cells.

  5. 5.Name an animal in which haploid cells divide by mitosis.Show answer

    Male honey bee.

  6. 6.What is the metaphase plate?Show answer

    The plane at the cell's equator where chromosomes line up during metaphase.

  7. 7.What is a syncytium? Give an example.Show answer

    A multinucleate cell formed when karyokinesis is not followed by cytokinesis; liquid endosperm of coconut.

  8. 8.What does the cell plate become?Show answer

    The middle lamella between the two new cells.

  9. 9.What is a bivalent?Show answer

    A pair of synapsed homologous chromosomes (also called a tetrad).

  10. 10.Which substage of prophase I can last months or years in some vertebrate oocytes?Show answer

    Diplotene.

  11. 11.Is DNA replicated during interkinesis?Show answer

    No.

  12. 12.How many cells form at the end of meiosis II from one meiocyte?Show answer

    Four haploid cells.

Best order to study it

  1. Learn the cell cycle: G1, S, G2, M and G0, with durations and what happens in each.
  2. Learn the four stages of mitosis with a 2n = 4 diagram for each, then cytokinesis in plants and animals.
  3. List the significance of mitosis.
  4. Learn the key features of meiosis, then prophase I substages one by one with their events.
  5. Learn metaphase I to telophase II, comparing each with mitosis.
  6. Practise tables of chromosome number and DNA content through mitosis and meiosis.

Quick revision checklist

The night before the exam: can you do each of these without looking?

  • Can you name the four sub-phases of interphase and G0 and say what happens in each?
  • Can you say why interphase is not truly a resting phase?
  • Can you describe each mitotic stage in three points?
  • Can you compare cytokinesis in plant and animal cells?
  • Can you give five points on the significance of mitosis?
  • Can you list the five substages of prophase I and their key events?
  • Can you say what separates in anaphase I and anaphase II?
  • Can you give n and C values at G1, G2, after meiosis I and after meiosis II?

Cell Cycle and Cell Division: frequently asked questions

How many marks does this chapter carry in Class 11 Biology (2026-27)?

Marks are set by unit. This chapter is in Unit III, Cell: Structure and Function, which carries 15 of the 70 theory marks together with Cell: The Unit of Life and Biomolecules.

Is the whole chapter in the 2026-27 syllabus?

Yes. The syllabus lists the cell cycle, mitosis, meiosis and their significance, which covers every section of the NCERT chapter.

What is the difference between a chromatid and a chromosome?

After S phase, each chromosome has two identical chromatids joined at the centromere. When the centromere splits at anaphase (or anaphase II), each chromatid becomes an independent daughter chromosome.

Why is meiosis I called the reduction division?

In anaphase I, homologous chromosomes go to opposite poles, so each daughter cell gets only one of each pair: the chromosome number is halved from 2n to n.

Do all four cells from meiosis survive?

The division produces four haploid cells. In many cases all four function as gametes or spores; in some cases, such as egg formation in many animals, the cells are unequal in size and only one becomes the functional egg.

Based on: CBSE Biology (044) syllabus 2026-27 (Classes XI-XII); NCERT Biology, Textbook for Class XI, Chapter 10 (Reprint 2026-27)