Skip to content

Lipoprotein lipase… (Class 12 Biology SQP 2023-24, Q27b)

questionbuddy.in/q/cbse-12-biology-2023-24-sqp-q27b-lipoprotein-lipase-deficiency-lpld-genetic

BiologyCBSE Class 12 · Sample paper, session 2023-24 · 3 marks · Short answer

CBSE Class 12 Biology sample paper 2023-24: question 27(b)

From the official CBSE sample question paper for 2023-24, section C, question 27(b), for 3 marks. Try it first; the hints and our step-by-step solution are below.

Q27(b) · 3 marks · Short answerCompetency-basedBiotechnology and its Applications

Lipoprotein lipase deficiency (LPLD) is a genetic disorder in which a person has a defective gene for lipase. This leads to high triglycerides, stomach pain, fat deposits under the skin. It may eventually affect the liver, pancreas and may also cause diabetes. The disorder occurs if a child acquires defective genes from both parents (autosomal recessive). ERT (enzyme replacement treatment) is one of the treatments offered to patients with LPLD.
a) (i) What procedure is followed in ERT?
(ii) What could be one possible drawback of ERT?
b) How can LPLD be treated using Biotechnology? Elaborate.

Source: official sample paper from cbseacademic.nic.in (PDF). See it in the full Sample paper 2023-24.

Hints

Open one hint at a time and try again before the next.

Hint 1

Compare this with the ADA-deficiency treatment described in NCERT.

Hint 2

Why must enzyme injections be repeated?

Hint 3

What biotechnology method fixes the faulty gene itself rather than just supplying the enzyme?

Step-by-step solution

Each step shows the marks it earns, as an examiner would award them. Checked by an independent re-solve from the question paper.

  1. a)(i) In ERT, the functional enzyme (lipoprotein lipase) is given to the patient by injection.

    ½ mark

  2. a)(ii) ERT is not a permanent cure. The injected enzyme is used up, so the patient needs repeated, lifelong doses.

    ½ mark

  3. b) LPLD can be treated by gene therapy.

    ½ mark

  4. Gene therapy is a collection of methods that correct a gene defect diagnosed in a child or embryo.

    ½ mark

  5. A normal (functional) lipase gene is delivered into the person's cells or tissues, for example using a disarmed viral vector. The gene takes over the function of the defective gene and compensates for it, so the patient makes functional enzyme. If introduced at an early embryonic stage, it could be a permanent cure.

    1 mark

Answer: a)(i) Functional lipase is injected; (ii) not curative, so repeated doses are needed. b) Gene therapy: a normal lipase gene is delivered into the patient's cells to compensate for the defective gene.

Where the marks are

  • ERT: functional enzyme given by injection (0.5 mark)
  • Drawback: not completely curative / repeated doses (0.5 mark)
  • Names gene therapy (0.5 mark)
  • Defines gene therapy (0.5 mark)
  • Normal gene delivered to compensate for the non-functional gene (1 mark)

Revise the chapter

Practise this chapterBoard-style questions from Biotechnology and its Applications, one at a time, marked against the answer key and marking points.Back to the full paperSample paper 2023-24: every question, by section.

The question is transcribed from the official paper; figures are described in words. The solution, hints and chapter tag are ours. Spotted an error? Write tosupport@questionbuddy.in.